China 52558-24-4 (S)-3-(tert-Butyloxycarbonylamino) -2-hydroxypropionicum acidum Manufacturer et Factory |Jiayinglai

52558-24-4 (S)-3-(tert-Butyloxycarbonylamino)-2-hydroxypropionicum acidum Featured Image

52558-24-4 (S) -3-(tert-Butyloxycarbonylamino) acidi -2-hydroxypropionici

Description:

Aspectus	Album ad Off-Crystallis alba vel crystallina pulveris.
MF	C8H15NO5
MW	205.21
Puritas	98+

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Product Detail

Transportatio conditio & commendatur naviculas modum:
per aerem, per mare vel per express

Repono conditione:
2-8°C

Ordinis Qty minimum:
Negatio

Certification:
COA, HPLC, GC, HNMR, Assay, Aqua Content (KF), TLC available

Synonyma

Acidum propanoicum, 3-[[(1,1-dimethylethoxy) carbonyl]amino]-2-hydroxy-, (2S)-;
(S) -3-(tert-Butyloxycarbonylamino) acidum -2-hydroxypropionicum;
2S) -3-[[(1,1-Dimethylethoxy) carbonyl]amino]-2-acidi hydroxy-propanoicum;
3-tert-butoxycarbonylaMino-(S)-2-acidi hydroxy-proponicum;
Boc-(S)-isoserine;
(S) -3-(Boc-aMino) -2-acidi hydroxy-propanoicum;
(S) -3-((tert-Butoxycarbonyl)aMino) -2-hydroxypropanoicum acidum;
(2S)-2-hydroxy-3-[(2-methylpropan-2-yl) oxycarbonylamino] acidum propanoicum

interiorem sarcina

Solent ad stipant pulveris.Et soles et aqua possunt prohibere mala questus.

exteriores sarcina

Lobortis duris res tuas ex fragore et umore questus protegere potest.

Applications

(S)-isoserinum 15a (21 g, 0,20 mol) dissolutum est in tetrahydrofuran (100 mL) Et mixtum solvens solutionis hydroxidi aquei 10percentis sodium (100 mL), Di-tert-butyl dicarbonatum (50 mL, 0.22 mol) erat addita dropwise. Reactio peracta est ad cella temperies per 9 horas. Phase aqueae pH 2 cum 4 mol/L acidi hydrochlorici adaequatum, et dichloromethane/methanolum extractum (v/v = 5/1, 50 mL × 3 ) et super anhydroum sodium sulfate exsiccatae. Filter suctu, coacervata coacta, Titulus compositi 15b consecutus est ut oleum sine colore (35 g, cede: 85percent).
Ad solutionem excitandam S-isoserinae (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1:1 v/v) ad 0° C addita est N-methylmorpholine (4.77 mL, 0.043 mol), quam sequitur BoC2O (11,28 mL, 0.049 mol) et reactionem pernoctare cum calefactione gradatim ad cubiculi temperiem commota est.Glycine (1.0 g, 0.013 mol) tunc addita est et reactionem pro 20 min excitata est.Reactio refrigerata est ad O0C et sedit aq.NaHCO3 (75 mL) addita.Stratum aqueum cum ethylo acetate ablutum est (2 x 60 mL) ac deinde acidificatum ad pH 1 cum NaHSO4.Haec solutio tunc cum ethyl acetate ( 3 x 70 mL) extracta est et hae compositiones organicae in Na2SO4 exsiccatae sunt, percolantur et coactae ad siccitatem dant desideratum acidum N-Boc-3-ammo-2(S) hydroxy- propanoicum. (6.30 g, 0.031 mmol, 81.5 cento cedat): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m. , 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H);13C NMR (IOO MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.
N-Boc-3-amino-2(S)-hydroxy-propionicum acidum ;Ad solutionem excitandam S-isoserinae (4.0 g, 0.038 mol) in dioxane: H2O (100 mL, 1:1 v/v) ad 0° C addita est N-methylmorpholine (4.77 mL, 0.043 mol), quam sequitur BoC2O (11,28 mL, 0.049 mol) et reactionem pernoctare cum calefactione gradatim ad cubiculi temperiem commota est.Glycine (1.0 g, 0.013 mol) tunc addita est et reactionem pro 20 min excitata est.Reactio ad 0°C refrigerata sedit aq.NaHCO3 (75 mL) addita.Stratum aqueum cum ethylo acetate ablutum est (2 x 60 mL) ac deinde acidificatum ad pH 1 cum NaHSO4.Haec solutio tunc cum ethyl acetate (3 x 70 mL) extracta est, et haec strata organica composita super Na2SO4 exsiccata sunt, percolata et coacta ad siccitatem ad desideratum N-Boc-3-amino-2(5) - hydroxy- propanoicum acidum. (6.30 g, 0.031 mmol, 81.5 cento cedat): 1H NMR (400 MHz, CDC13) δ 7.45 (bs, 1 H), 5.28 (bs, 1 H), 4.26 (m, 1 H), 3.40-3.62 (m. , 2 H), 2.09 (s, 1 H), 1.42 (s, 9 H);13C NMR (100 MHz, CDC13) δ 174.72, 158.17, 82, 71.85, 44.28, 28.45.

Related Products

Boc-Isoserine	Boc-L-ser(me).DCHA
L-Ser	Boc-DL-Ser(me)-OH
H-DL-Ser-OH	Boc-D-ser(me)-OH
D-Ser-OH	Boc-L-Ser(tBu)-OH
HL-Ser(Me)-OH.HCl	Boc-D-Ser(tBu)-OH
DL-Ser(Me)-OH	Boc-D-Ser(Tbu).DCHA
D-Ser(me)	Boc-L-Ser(Bzl)-OH
HL-Ser(tBu)-OH	Boc-DL-Ser(Bzl)-OH
D-Ser(tBu)-OH	Boc-D-Ser(Bzl)-OH
D-Ser(bzl)	Boc-L-Ser-OMe
D-Ser(bzl).HCl	Boc-DL-Ser-Ome
L-Ser(AC).Hcl	Boc-D-Ser-OMe
O-AC-Ser.Hcl	Boc-D-Ser-Oet
O-AC-L-Ser-OH	Boc-L-Ser-Obzl
HL-Ser(Bzl)-OH.HCl	Boc-D-Ser-Obzl
HL-Ser(Bzl)-OH	Fmoc-L-Ser-OH
HL-Ser-OMe.HCl	Fmoc-D-Ser-OH
H-DL-Ser-OMe·HCl	Fmoc-L-Ser(tBu)-OH
HD-Ser-OMe·HCl	Fmoc-D-Ser(tBu)-OH
L-Ser-Oet.Hcl	Fmoc-L-Ser(bzl)-OH
D-Ser-Oet.HCl	Fmoc-D-Ser(bzl)-OH
HL-Ser-OBzl.HCl	Fmoc-L-Ser-Obzl
HL-Ser-OBzl	Fmoc-N-Me-L-Ser(tBu)-OH
DL-Ser-Obzl.Hcl	Fmoc-N-Me-Ser(bzl)
D-Ser-Obzl.Hcl	Trt-L-Ser-Ome
D-Ser(me)-Ome.Hcl	Cbz-L-Ser-OH
HL-Ser(tBu)-OMe	Cbz-DL-Ser
H-Ser(tBu)-OMe.HCl	Cbz-D-Ser-OH
HD-Ser(tBu)-OMe	Cbz-L-Ser(tBu)-OH
HD-Ser(tBu)-OMe.HCl	ZL-Ser(Bzl)-OH
L-Ser(tbu)Oet	Cbz-D-Ser(Bzl)-OH
L-Ser(tbu)-Oet.HCl	Cbz-L-Ser-Ome
L-Ser(tBu)-OtBu	Cbz-DL-Ser-ome
L-Ser(tbu)-Otbu.Hcl	Cbz-D-Ser-Ome
D-Ser(tbu)-otbu.hcl	Cbz-L-Ser-Obzl
HL-Ser(Bzl)-OMe·HCl	Fmoc-L-Thr(tBu)-Ser-OH
Boc-L-Ser-OH	Boc-D-Ser-OH
Boc-L-Ser.H2O	Boc-L-ser(me)-OH
Boc-DL-Ser-OH

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